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cisplatin

Term Information

Accession
CHEBI:27899
Name
cisplatin
Ontology
Synonyms
(SP-4-2)-diamminedichloridoplatinum, (SP-4-2)-diamminedichloroplatinum, Cisplatin, cis-diamminedichloridoplatinum(II), cis-diamminedichloroplatinum(II), Briplatin, CDDP, Cismaplat, Lederplatin, Neoplatin, Peyrone's chloride, Peyrone's salt, Platamine, Platinex, Platinol, Randa, [PtCl2(NH3)2], cis-DDP, cis-Diamminedichloroplatinum(II), cis-[PtCl2(NH3)2], cis-diamminedichloroplatinum, cis-diammineplatinum(II) dichloride, cis-dichlorodiammineplatinum(II), cis-platin, cisplatin, cisplatine, cisplatino, cisplatinum
Alternate IDs
None
Definition
A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups). [source: unknown]
Comment
None
Subset
None
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Parents of cisplatin (CHEBI:27899)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
cisplatin [RO:0000087 relation] RO:0000087  genotoxin (CHEBI:50902)
cisplatin [RO:0000087 relation] RO:0000087  cross-linking reagent (CHEBI:50684)
cisplatin [RO:0000087 relation] RO:0000087  antineoplastic agent (CHEBI:35610)
cisplatin [is_a relation] is_a  diamminedichloroplatinum (CHEBI:51214)
cisplatin [RO:0000087 relation] RO:0000087  mutagen (CHEBI:25435)
cisplatin [RO:0000087 relation] RO:0000087  nephrotoxin (CHEBI:61015)
cisplatin [RO:0000087 relation] RO:0000087  photosensitizing agent (CHEBI:47868)

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