Planteome: Term Details for "tRNA wobble position uridine thiolation" (GO:0002143)

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Term Information

Accession: GO:0002143
Name: tRNA wobble position uridine thiolation
Ontology: biological_process
Synonyms: tRNA wobble uridine thiolation, wobble position s2U biosynthesis
Alternate IDs: None
Definition: The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps. Source: PMID:16871210
Comment: In E. coli, the first step of the reaction is reductive elimination of sulfur from L-cysteine by IscS cysteine desulfurase to form an enzyme-bound cysteine-persulfide intermediate. Then, five essential gene products, TusA, TusB, TusC, TusD and TusE, mediate a sulfur relay that delivers the terminal sulfur of persulfide from IscS to MnmA12. The last protein, MnmA catalyzes the transfer of the sulfur from IscS to an ATP activated U34 of the tRNA.
History: See term history for GO:0002143 at QuickGO
Subset: None
Related: Link to all annotated objects annotated to tRNA wobble position uridine thiolation.; Link to all direct and indirect annotations to tRNA wobble position uridine thiolation.; Link to all direct and indirect annotations download (limited to first 10,000) for tRNA wobble position uridine thiolation.
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BFO:0000001 entity
BFO:0000003 occurrent
GO:0008150 biological_process
GO:0009987 cellular process
GO:0008152 metabolic process
BFO:0000015 process
GO:0044237 cellular metabolic process
GO:0006807 nitrogen compound metabolic process
GO:0071704 organic substance metabolic process
GO:0006725 cellular aromatic compound metabolic process
GO:0034641 cellular nitrogen compound metabolic process
GO:0046483 heterocycle metabolic process
GO:0043170 macromolecule metabolic process
GO:1901360 organic cyclic compound metabolic process
GO:0044238 primary metabolic process
GO:0010467 gene expression
GO:0006139 nucleobase-containing compound metabolic process
GO:0016070 RNA metabolic process
GO:0034660 ncRNA metabolic process
GO:0090304 nucleic acid metabolic process
GO:0006396 RNA processing
GO:0043412 macromolecule modification
GO:0034470 ncRNA processing
GO:0006399 tRNA metabolic process
GO:0009451 RNA modification
GO:0006400 tRNA modification
GO:0008033 tRNA processing
GO:0002097 tRNA wobble base modification
GO:0034227 tRNA thio-modification
GO:0002098 tRNA wobble uridine modification
GO:0002143 tRNA wobble position uridine thiolation
GO:1990799 mitochondrial tRNA wobble position uridine thiolation

Parents of tRNA wobble position uridine thiolation (GO:0002143)

subject	relation	object
tRNA wobble position uridine thiolation	is_a	tRNA thio-modification (GO:0034227)
tRNA wobble position uridine thiolation	is_a	tRNA wobble uridine modification (GO:0002098)

Children of tRNA wobble position uridine thiolation (GO:0002143)

subject	relation	object
mitochondrial tRNA wobble position uridine thiolation (GO:1990799)	is_a	tRNA wobble position uridine thiolation