Planteome: Term Details for "marginal zone B cell differentiation" (GO:0002315)

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Term Information

Accession: GO:0002315
Name: marginal zone B cell differentiation
Ontology: biological_process
Synonyms: marginal zone B lymphocyte differentiation, marginal zone B-cell differentiation, marginal zone B-lymphocyte differentiation, marginal zone B cell development
Alternate IDs: None
Definition: The process in which a B cell in the spleen acquires the specialized features of a marginal zone B cell. Marginal zone B cells are localized in a distinct anatomical region of the spleen that represents the major antigen-filtering and scavenging area (by specialized macrophages resident there). It appears that they are preselected to express a BCR repertoire similar to B-1 B cells, biased toward bacterial cell wall constituents and senescent self-components (such as oxidized LDL). Source: ISBN:0781735149, GOC:jal
Comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
History: See term history for GO:0002315 at QuickGO
Subset: None
Related: Link to all annotated objects annotated to marginal zone B cell differentiation.; Link to all direct and indirect annotations to marginal zone B cell differentiation.; Link to all direct and indirect annotations download (limited to first 10,000) for marginal zone B cell differentiation.
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