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Term Information

Accession
GO:0002420
Name
natural killer cell mediated cytotoxicity directed against tumor cell target
Ontology
biological_process
Synonyms
NK cell mediated cytotoxicity directed against tumor cell target
Alternate IDs
None
Definition
The directed killing of a tumor cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors. Source: PMID:16730260, ISBN:0781735149, GOC:add
Comment
Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell.
History
See term history for GO:0002420 at QuickGO
Subset
None
Feedback
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Graph of GO:0002420

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Parents of natural killer cell mediated cytotoxicity directed against tumor cell target (GO:0002420)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
natural killer cell mediated cytotoxicity directed against tumor cell target [is_a relation] is_a  natural killer cell mediated immune response to tumor cell (GO:0002423)
natural killer cell mediated cytotoxicity directed against tumor cell target [is_a relation] is_a  natural killer cell mediated cytotoxicity (GO:0042267)
Children of natural killer cell mediated cytotoxicity directed against tumor cell target (GO:0002420)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
regulation of natural killer cell mediated cytotoxicity directed against tumor cell target (GO:0002858) [RO:0002211 relation] RO:0002211  natural killer cell mediated cytotoxicity directed against tumor cell target
positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target (GO:0002860) [RO:0002213 relation] RO:0002213  natural killer cell mediated cytotoxicity directed against tumor cell target
negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target (GO:0002859) [RO:0002212 relation] RO:0002212  natural killer cell mediated cytotoxicity directed against tumor cell target
None.