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Term Information

Accession
GO:0004517
Name
nitric-oxide synthase activity
Ontology
molecular_function
Synonyms
nitric oxide synthase activity, L-arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) activity, NADPH-diaphorase activity, NO synthase activity, endothelium-derived relaxation factor-forming enzyme activity, endothelium-derived relaxing factor synthase activity, nitric oxide synthetase activity, nitric-oxide synthetase activity
Alternate IDs
None
Definition
Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+. Source: EC:1.14.13.39, RHEA:19897
Comment
None
History
See term history for GO:0004517 at QuickGO
Subset
None
Feedback
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Graph of GO:0004517

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Parents of nitric-oxide synthase activity (GO:0004517)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
nitric-oxide synthase activity [is_a relation] is_a  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen (GO:0016709)
Children of nitric-oxide synthase activity (GO:0004517)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
negative regulation of nitric-oxide synthase activity (GO:0051001) [RO:0002212 relation] RO:0002212  nitric-oxide synthase activity
regulation of nitric-oxide synthase activity (GO:0050999) [RO:0002211 relation] RO:0002211  nitric-oxide synthase activity
positive regulation of nitric-oxide synthase activity (GO:0051000) [RO:0002213 relation] RO:0002213  nitric-oxide synthase activity