Planteome: Term Details for "phospholipase A2 activity" (GO:0004623)

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Term Information

Accession: GO:0004623
Name: phospholipase A2 activity
Ontology: molecular_function
Synonyms: lecithinase A activity, phosphatidase activity, phosphatidolipase activity, phosphatidylcholine 2-acylhydrolase activity, cytosolic phospholipase A2 activity, phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine), phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine), secreted phospholipase A2 activity
Alternate IDs: GO:0102568, GO:0102567
Definition: Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospholipid + H2O = 1-acyl-sn-glycero-3-phospholipid + a fatty acid. This reaction removes the fatty acid attached to the sn2-position. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides. Source: RHEA:15801
Comment: None
History: See term history for GO:0004623 at QuickGO
Subset: goslim_chembl
Related: Link to all annotated objects annotated to phospholipase A2 activity.; Link to all direct and indirect annotations to phospholipase A2 activity.; Link to all direct and indirect annotations download (limited to first 10,000) for phospholipase A2 activity.
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BFO:0000001 entity
BFO:0000003 occurrent
BFO:0000015 process
GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0016787 hydrolase activity
GO:0016788 hydrolase activity, acting on ester bonds
GO:0016298 lipase activity
GO:0052689 carboxylic ester hydrolase activity
GO:0004620 phospholipase activity
GO:0004623 phospholipase A2 activity
GO:0047498 calcium-dependent phospholipase A2 activity
GO:0047499 calcium-independent phospholipase A2 activity
GO:1900138 negative regulation of phospholipase A2 activity
GO:0032430 positive regulation of phospholipase A2 activity
GO:0032429 regulation of phospholipase A2 activity

Parents of phospholipase A2 activity (GO:0004623)

subject	relation	object
phospholipase A2 activity	is_a	phospholipase activity (GO:0004620)
phospholipase A2 activity	is_a	carboxylic ester hydrolase activity (GO:0052689)

Children of phospholipase A2 activity (GO:0004623)

subject	relation	object
negative regulation of phospholipase A2 activity (GO:1900138)	RO:0002212	phospholipase A2 activity
regulation of phospholipase A2 activity (GO:0032429)	RO:0002211	phospholipase A2 activity
calcium-dependent phospholipase A2 activity (GO:0047498)	is_a	phospholipase A2 activity
positive regulation of phospholipase A2 activity (GO:0032430)	RO:0002213	phospholipase A2 activity
calcium-independent phospholipase A2 activity (GO:0047499)	is_a	phospholipase A2 activity

EC: 3.1.1.4
MetaCyc: RXN-15067; PHOSPHOLIPASE-A2-RXN
Reactome: R-HSA-1482825; R-HSA-1482907; R-HSA-1482884; R-HSA-1482745; R-HSA-1482887; R-HSA-1482868; R-HSA-1482604; R-HSA-1482900; R-HSA-1602417; R-HSA-1482771; R-HSA-1602374; R-HSA-1602398; R-HSA-1602377; R-HSA-1602399; R-HSA-1482759; R-HSA-1482816; R-HSA-1482897; R-HSA-1482776; R-HSA-1482679; R-HSA-1482778; R-HSA-1482656; R-HSA-1482856; R-HSA-1602446; R-HSA-1602368; R-HSA-8848484
RHEA: 15801