Planteome: Term Details for "guanyl-nucleotide exchange factor activity" (GO:0005085)

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Term Information

Accession: GO:0005085
Name: guanyl-nucleotide exchange factor activity
Ontology: molecular_function
Synonyms: GDP-dissociation stimulator activity, GDS, GEF, guanyl-nucleotide release factor activity, guanyl-nucleotide releasing factor, GNRP
Alternate IDs: GO:0019839, GO:0016219, GO:0008433
Definition: Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. Source: GOC:mah, GOC:kd
Comment: Note that guanyl-nucleotide exchange factor (GEF) activity alters binding affinity, but not GTPase catalytic activity directly. Therefore GO:0005085 is under 'regulation of GTPase activity' but is not a 'GTPase regulator', which is reserved for cases where the action of one gene product directly alters the rate of catalysis by another gene product.
History: See term history for GO:0005085 at QuickGO
Subset: goslim_chembl; goslim_drosophila; goslim_yeast
Related: Link to all annotated objects annotated to guanyl-nucleotide exchange factor activity.; Link to all direct and indirect annotations to guanyl-nucleotide exchange factor activity.; Link to all direct and indirect annotations download (limited to first 10,000) for guanyl-nucleotide exchange factor activity.
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BFO:0000001 entity
GO:0003674 molecular_function
BFO:0000015 process
GO:0005488 binding
GO:0008150 biological_process
BFO:0000003 occurrent
GO:0065007 biological regulation
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0065009 regulation of molecular function
GO:0051020 GTPase binding
GO:0098772 molecular function regulator
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005086 ARF guanyl-nucleotide exchange factor activity
GO:0017132 cAMP-dependent guanyl-nucleotide exchange factor activity
GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity
GO:1905099 positive regulation of guanyl-nucleotide exchange factor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:1905097 regulation of guanyl-nucleotide exchange factor activity
GO:0005090 Sar guanyl-nucleotide exchange factor activity

Parents of guanyl-nucleotide exchange factor activity (GO:0005085)

subject	relation	object
guanyl-nucleotide exchange factor activity	is_a	molecular function regulator (GO:0098772)
guanyl-nucleotide exchange factor activity	is_a	GTPase binding (GO:0051020)

Children of guanyl-nucleotide exchange factor activity (GO:0005085)

subject	relation	object
Sar guanyl-nucleotide exchange factor activity (GO:0005090)	is_a	guanyl-nucleotide exchange factor activity
Ras guanyl-nucleotide exchange factor activity (GO:0005088)	is_a	guanyl-nucleotide exchange factor activity
positive regulation of guanyl-nucleotide exchange factor activity (GO:1905099)	RO:0002213	guanyl-nucleotide exchange factor activity
regulation of guanyl-nucleotide exchange factor activity (GO:1905097)	RO:0002211	guanyl-nucleotide exchange factor activity
cAMP-dependent guanyl-nucleotide exchange factor activity (GO:0017132)	is_a	guanyl-nucleotide exchange factor activity
negative regulation of guanyl-nucleotide exchange factor activity (GO:1905098)	RO:0002212	guanyl-nucleotide exchange factor activity
ARF guanyl-nucleotide exchange factor activity (GO:0005086)	is_a	guanyl-nucleotide exchange factor activity

Reactome: R-HSA-5694409; R-HSA-354173; R-HSA-9640167; R-HSA-9666428; R-HSA-8851899; R-HSA-5218850; R-HSA-187746; R-HSA-3928628; R-HSA-2029467; R-HSA-9666430; R-HSA-205039; R-HSA-392195; R-HSA-420883; R-HSA-389348; R-HSA-2485180; R-HSA-392870; R-HSA-203977; R-HSA-751029; R-HSA-749453; R-HSA-416530; R-HSA-442291; R-HSA-428750; R-HSA-8982640; R-HSA-8875568; R-HSA-170979; R-HSA-5218839; R-HSA-8850041; R-HSA-1433415; R-HSA-3928651; R-HSA-114544; R-HSA-3928612; R-HSA-2029451; R-HSA-428917; R-HSA-8982637; R-HSA-825631; R-HSA-4093336; R-HSA-9660824; R-HSA-379044; R-HSA-1168636; R-HSA-5218829; R-HSA-939265; R-HSA-8851877; R-HSA-2424476; R-HSA-156913; R-HSA-6807868; R-HSA-169904; R-HSA-2029445; R-HSA-2730840; R-HSA-379048; R-HSA-380073; R-HSA-3928642; R-HSA-9639286; R-HSA-445064; R-HSA-8851827; R-HSA-389350; R-HSA-3928592; R-HSA-418579; R-HSA-442273; R-HSA-8848618; R-HSA-6811429; R-HSA-8964604; R-HSA-3965444; R-HSA-8875591; R-HSA-3928632; R-HSA-399995; R-HSA-3928633; R-HSA-442314