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G protein-coupled receptor signaling pathway
Term Information
Accession
GO:0007186
Name
G protein-coupled receptor signaling pathway
Ontology
biological_process
Synonyms
G protein coupled receptor protein signaling pathway, G protein coupled receptor protein signalling pathway, G-protein coupled receptor protein signal transduction, G-protein coupled receptor protein signaling pathway, G-protein coupled receptor signalling pathway, G-protein-coupled receptor protein signalling pathway, GPCR signaling pathway, GPCR signalling pathway, G-protein coupled receptor signaling pathway via GPCR dimer, dimeric G-protein coupled receptor signaling pathway, dimeric G-protein coupled receptor signalling pathway
Alternate IDs
GO:0038042
Definition
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane.
Source:Wikipedia:G_protein-coupled_receptor,
PMID:24568158,
PMID:16902576,
GOC:bf,
GOC:mah
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