Planteome: Term Details for "I-kappaB kinase/NF-kappaB signaling" (GO:0007249)

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Term Information

Accession: GO:0007249
Name: I-kappaB kinase/NF-kappaB signaling
Ontology: biological_process
Synonyms: I-kappaB kinase/NF-kappaB signal transduction, canonical NF-kappaB signaling cascade, I-kappaB kinase/NF-kappaB cascade, activation of the inhibitor of kappa kinase, p50-dependent NF-kappaB signaling, NF-kappaB cascade
Alternate IDs: None
Definition: The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. Source: PMID:12773372, GOC:jl, GOC:bf, Reactome:R-HSA-209560
Comment: None
History: See term history for GO:0007249 at QuickGO
Subset: None
Related: Link to all annotated objects annotated to I-kappaB kinase/NF-kappaB signaling.; Link to all direct and indirect annotations to I-kappaB kinase/NF-kappaB signaling.; Link to all direct and indirect annotations download (limited to first 10,000) for I-kappaB kinase/NF-kappaB signaling.
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BFO:0000001 entity
BFO:0000003 occurrent
GO:0008150 biological_process
GO:0065007 biological regulation
BFO:0000015 process
GO:0009987 cellular process
GO:0005575 cellular_component
GO:0050789 regulation of biological process
GO:0050896 response to stimulus
GO:0007154 cell communication
GO:0110165 cellular anatomical entity
GO:0051716 cellular response to stimulus
GO:0050794 regulation of cellular process
GO:0023052 signaling
GO:0005622 intracellular anatomical structure
GO:0007165 signal transduction
GO:0035556 intracellular signal transduction
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007252 I-kappaB phosphorylation
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling

Parents of I-kappaB kinase/NF-kappaB signaling (GO:0007249)

subject	relation	object
I-kappaB kinase/NF-kappaB signaling	is_a	intracellular signal transduction (GO:0035556)
I-kappaB kinase/NF-kappaB signaling	BFO:0000051	positive regulation of NF-kappaB transcription factor activity (GO:0051092)

Children of I-kappaB kinase/NF-kappaB signaling (GO:0007249)

subject	relation	object
epidermal growth factor receptor signaling pathway via I-kappaB kinase/NF-kappaB cascade (GO:0038168)	BFO:0000051	I-kappaB kinase/NF-kappaB signaling
negative regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043124)	RO:0002212	I-kappaB kinase/NF-kappaB signaling
regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043122)	RO:0002211	I-kappaB kinase/NF-kappaB signaling
positive regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043123)	RO:0002213	I-kappaB kinase/NF-kappaB signaling
I-kappaB phosphorylation (GO:0007252)	BFO:0000050	I-kappaB kinase/NF-kappaB signaling