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DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity

Term Information

Accession
GO:0008657
Name
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity
Ontology
molecular_function
Synonyms
DNA gyrase inhibitor activity
Alternate IDs
None
Definition
Binds to and stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. Source: GOC:mah
Comment
None
History
See term history for GO:0008657 at QuickGO
Subset
None
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Parents of DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity (GO:0008657)
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DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity [is_a relation] is_a  DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) regulator activity (GO:0072586)
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity [is_a relation] is_a  enzyme inhibitor activity (GO:0004857)
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity [is_a relation] is_a  ATPase inhibitor activity (GO:0042030)

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