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Term Information

Accession
GO:0012501
Name
programmed cell death
Ontology
biological_process
Synonyms
PCD, RCD, caspase-independent apoptosis, caspase-independent cell death, non-apoptotic programmed cell death, nonapoptotic programmed cell death, regulated cell death
Alternate IDs
GO:0016244
Definition
A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell. Source: GOC:lr, GOC:mtg_apoptosis
Comment
Note that this term should be used to annotate gene products in the organism undergoing the programmed cell death. To annotate genes in another organism whose products modulate programmed cell death in a host organism, consider the term 'modulation by symbiont of host programmed cell death ; GO:0052040'. Also, note that 'programmed cell death ; GO:0012501' should be used to refer to instances of caspase-independent cell death mechanisms, in the absence of further indications on the process taking place. At present, caspase-independent cell death is not yet represented in GO due to the lack of consensus and in-depth research on the topic. 'programmed cell death ; GO:0012501' may also be used to annotate gene products in taxa where apoptosis as defined in GO:0006915 does not occur, such as plants. You may also consider these specific children: GO:0097468 'programmed cell death in response to reactive oxygen species' (with descendants GO:0010421 'hydrogen peroxide-mediated programmed cell death' and GO:0010343 'singlet oxygen-mediated programmed cell death'), and GO:0009626 'plant-type hypersensitive response' and its children.
History
See term history for GO:0012501 at QuickGO
Subset
goslim_drosophila
goslim_chembl
goslim_plant
goslim_generic
prokaryote_subset
goslim_mouse
goslim_agr
Feedback
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Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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Graph of GO:0012501

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Parents of programmed cell death (GO:0012501)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
programmed cell death [is_a relation] is_a  cell death (GO:0008219)
Children of programmed cell death (GO:0012501)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
programmed necrotic cell death (GO:0097300) [is_a relation] is_a  programmed cell death
granzyme-mediated programmed cell death signaling pathway (GO:0140507) [BFO:0000050 relation] BFO:0000050  programmed cell death
death receptor activity (GO:0005035) [BFO:0000050 relation] BFO:0000050  programmed cell death
programmed cell death involved in cell development (GO:0010623) [is_a relation] is_a  programmed cell death
suppression by symbiont of host programmed cell death (GO:0052041) [RO:0002212 relation] RO:0002212  programmed cell death
modulation by symbiont of host programmed cell death (GO:0052040) [RO:0002211 relation] RO:0002211  programmed cell death
regulation of programmed cell death (GO:0043067) [RO:0002211 relation] RO:0002211  programmed cell death
pyroptosis (GO:0070269) [is_a relation] is_a  programmed cell death
positive regulation of programmed cell death (GO:0043068) [RO:0002213 relation] RO:0002213  programmed cell death
autolysis (GO:0001896) [is_a relation] is_a  programmed cell death
cornification (GO:0070268) [is_a relation] is_a  programmed cell death
apoptotic process (GO:0006915) [is_a relation] is_a  programmed cell death
mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686) [BFO:0000050 relation] BFO:0000050  programmed cell death
autophagic cell death (GO:0048102) [is_a relation] is_a  programmed cell death
programmed cell death induced by symbiont (GO:0034050) [is_a relation] is_a  programmed cell death
programmed cell death in response to retinoic acid (GO:0160059) [is_a relation] is_a  programmed cell death
programmed cell death in response to reactive oxygen species (GO:0097468) [is_a relation] is_a  programmed cell death
ferroptosis (GO:0097707) [is_a relation] is_a  programmed cell death
negative regulation of programmed cell death (GO:0043069) [RO:0002212 relation] RO:0002212  programmed cell death