Planteome: Term Details for "polyketide synthase activity" (GO:0016218)

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Term Information

Accession: GO:0016218
Name: polyketide synthase activity
Ontology: molecular_function
Synonyms: PKS activity
Alternate IDs: None
Definition: Catalysis of a multistep reaction that produce polyketides through decarboxylative condensation of carboxylic acids. The key chain-building reaction, a C-N bond-forming reaction, involves the generation of the characteristic peptide bond by nucleophilic attack of the amino group of an amino-acyl donor unit covalently bound to a downstream peptidyl carrier protein module (amino acyl-S-PCP) on the acyl group of an upstream electrophilic acyl- or peptidyl acyl-S-PCP chain, catalyzed by a condensation (C) domain. Supplementing these core chain-elongation domains are variable numbers of auxiliary domains that are responsible for modification of the growing polypeptide chain by a small set of iterated reactions including epimerization, N-methylation, and heterocyclization. Source: PMID:10631508
Comment: None
History: See term history for GO:0016218 at QuickGO
Subset: None
Related: Link to all annotated objects annotated to polyketide synthase activity.; Link to all direct and indirect annotations to polyketide synthase activity.; Link to all direct and indirect annotations download (limited to first 10,000) for polyketide synthase activity.
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