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core-binding factor complex
Term Information
Accession
GO:0016513
Name
core-binding factor complex
Ontology
cellular_component
Synonyms
CBF complex, AML1 complex, PEPB2 complex
Alternate IDs
None
Definition
A heterodimeric transcription factor complex that contains an alpha subunit (Runx1, Runx2 or Runx3 in human) that binds DNA and a non-DNA-binding beta subunit (CBFbeta), and binds to a consensus sequence 5'-YGYGGTY-3' found in several enhancers and promoters; the beta subunit enhances the DNA binding of the alpha subunit.
Source:PMID:8497254,
PMID:15156179
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