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eukaryotic 48S preinitiation complex

Term Information

Accession
GO:0033290
Name
eukaryotic 48S preinitiation complex
Ontology
cellular_component
Synonyms
eukaryotic 48S pre-initiation complex, eukaryotic 48S initiation complex
Alternate IDs
GO:0016283
Definition
The protein-ribosome-tRNA complex that has just recognized the start codon of a capped mRNA. It is composed of the small ribosomal subunit, eukaryote initiation factors (eIF) eIF3 complex, eIF1, eIF1A, eIF2-GDP, eIF4 complex and initiatior-methionine-tRNA. Recognition of the start codon triggers downstream steps in the pathway, including eIF1 dissociation; Pi release from eIF2; and conversion to the closed, scanning-arrested conformation of the PIC. Source: PMID:16510876, PMID:24499181, PMID:24319994, PMID:29735639, GOC:hjd
Comment
None
History
See term history for GO:0033290 at QuickGO
Subset
None
Feedback
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Graph of GO:0033290

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Parents of eukaryotic 48S preinitiation complex (GO:0033290)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
eukaryotic 48S preinitiation complex [BFO:0000051 relation] BFO:0000051  cytosolic small ribosomal subunit (GO:0022627)
eukaryotic 48S preinitiation complex [is_a relation] is_a  translation preinitiation complex (GO:0070993)

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