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Term Information

Accession
GO:0034205
Name
amyloid-beta formation
Ontology
biological_process
Synonyms
beta-amyloid formation, beta-amyloid polypeptide formation from APP, beta-amyloid polypeptide formation from amyloid precursor protein
Alternate IDs
None
Definition
The generation of amyloid-beta by cleavage of the amyloid precursor protein (APP). Source: GOC:mah
Comment
Note that this term does not fall under the general GO definition for biosynthetic processes, which is 'The chemical reactions and pathways resulting in the formation of... ', because amyloid-beta can only be formed by the proteolysis of a larger molecule (see term definition). The word 'formation' is therefore used in place of biosynthesis. Also, note that this term refers to the production of the amyloid-beta polypeptide from the amyloid precursor protein (APP), and should be used to annotate e.g. secretases that cleave APP to form amyloid-beta. To annotate gene products involved in the formation of amyloid fibrils, please consider 'amyloid fibril formation' (GO:1990000).
History
See term history for GO:0034205 at QuickGO
Subset
None
Feedback
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Graph of GO:0034205

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Parents of amyloid-beta formation (GO:0034205)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
amyloid-beta formation [is_a relation] is_a  amyloid precursor protein catabolic process (GO:0042987)
amyloid-beta formation [is_a relation] is_a  amyloid-beta metabolic process (GO:0050435)
Children of amyloid-beta formation (GO:0034205)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
regulation of amyloid-beta formation (GO:1902003) [RO:0002211 relation] RO:0002211  amyloid-beta formation
positive regulation of amyloid-beta formation (GO:1902004) [RO:0002213 relation] RO:0002213  amyloid-beta formation
negative regulation of amyloid-beta formation (GO:1902430) [RO:0002212 relation] RO:0002212  amyloid-beta formation
None.