Planteome: Term Details for "miRNA-mediated gene silencing" (GO:0035195)

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Term Information

Accession: GO:0035195
Name: miRNA-mediated gene silencing
Ontology: biological_process
Synonyms: gene silencing by miRNA, gene silencing by microRNA, microRNA-mediated gene silencing
Alternate IDs: None
Definition: A post-transcriptional gene silencing pathway in which regulatory microRNAs (miRNAs) elicit silencing of specific target genes. miRNAs are endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate protein production by either of two posttranscriptional mechanisms: endonucleolytic cleavage of the RNA (often mRNA) or mRNA translational repression, usually accompanied by poly-A tail shortening and subsequent degradation of the mRNA. miRNAs are present in all the animals and in plants, whereas siRNAs are present in lower animals and in plants. Source: PMID:28379604, PMID:23985560, GOC:bc, PMID:15066283, PMID:14744438, GOC:aruk, PMID:15066275, GOC:rl, PMID:23209154
Comment: None
History: See term history for GO:0035195 at QuickGO
Subset: None
Related: Link to all annotated objects annotated to miRNA-mediated gene silencing.; Link to all direct and indirect annotations to miRNA-mediated gene silencing.; Link to all direct and indirect annotations download (limited to first 10,000) for miRNA-mediated gene silencing.
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BFO:0000001 entity
BFO:0000003 occurrent
GO:0008150 biological_process
GO:0065007 biological regulation
BFO:0000015 process
GO:0008152 metabolic process
GO:0050789 regulation of biological process
GO:0043170 macromolecule metabolic process
GO:0048519 negative regulation of biological process
GO:0071704 organic substance metabolic process
GO:0019222 regulation of metabolic process
GO:0010467 gene expression
GO:0009892 negative regulation of metabolic process
GO:0060255 regulation of macromolecule metabolic process
GO:0010605 negative regulation of macromolecule metabolic process
GO:0010468 regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010608 post-transcriptional regulation of gene expression
GO:0016441 post-transcriptional gene silencing
GO:0031047 regulatory ncRNA-mediated gene silencing
GO:0035194 regulatory ncRNA-mediated post-transcriptional gene silencing
GO:0035195 miRNA-mediated gene silencing
GO:0035278 miRNA-mediated gene silencing by inhibition of translation
GO:0035279 miRNA-mediated gene silencing by mRNA destabilization
GO:0060965 negative regulation of miRNA-mediated gene silencing
GO:2000637 positive regulation of miRNA-mediated gene silencing
GO:0035281 pre-miRNA export from nucleus
GO:0060964 regulation of miRNA-mediated gene silencing

Parents of miRNA-mediated gene silencing (GO:0035195)

subject	relation	object
miRNA-mediated gene silencing	is_a	regulatory ncRNA-mediated post-transcriptional gene silencing (GO:0035194)

Children of miRNA-mediated gene silencing (GO:0035195)

subject	relation	object
positive regulation of miRNA-mediated gene silencing (GO:2000637)	RO:0002213	miRNA-mediated gene silencing
miRNA-mediated gene silencing by mRNA destabilization (GO:0035279)	is_a	miRNA-mediated gene silencing
negative regulation of miRNA-mediated gene silencing (GO:0060965)	RO:0002212	miRNA-mediated gene silencing
regulation of miRNA-mediated gene silencing (GO:0060964)	RO:0002211	miRNA-mediated gene silencing
pre-miRNA export from nucleus (GO:0035281)	BFO:0000050	miRNA-mediated gene silencing
miRNA-mediated gene silencing by inhibition of translation (GO:0035278)	is_a	miRNA-mediated gene silencing