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Term Information

Accession
GO:0035369
Name
pre-B cell receptor complex
Ontology
cellular_component
Synonyms
pre-BCR
Alternate IDs
None
Definition
An immunoglobulin-like complex that is present in at least the plasma membrane of pre-B cells, and that is composed of two identical immunoglobulin heavy chains and two surrogate light chains, each composed of the lambda-5 and VpreB proteins, and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins. Source: ISBN:0781765196, PMID:16464608, GOC:add, PMID:17306522
Comment
Despite its name, the pre-BCR is not a receptor complex, as it appears to provide a low level of signal not dependent on a ligand, but rather simply on correct assembly of the complex as a measure for correct Ig heavy chain recombination and folding. A significant proportion of pre-BCR complexes fail to reach the cell surface, and in some cases may provide their signaling function from the trans-Golgi network or lysosome.
History
See term history for GO:0035369 at QuickGO
Subset
None
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Graph of GO:0035369

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Parents of pre-B cell receptor complex (GO:0035369)
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pre-B cell receptor complex [is_a relation] is_a  membrane protein complex (GO:0098796)

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