You are using the Cyverse mirror of the Planteome Ontology Browser. The main site is at browser.planteome.org.
pre-B cell receptor complex
Term Information
Accession
GO:0035369
Name
pre-B cell receptor complex
Ontology
cellular_component
Synonyms
pre-BCR
Alternate IDs
None
Definition
An immunoglobulin-like complex that is present in at least the plasma membrane of pre-B cells, and that is composed of two identical immunoglobulin heavy chains and two surrogate light chains, each composed of the lambda-5 and VpreB proteins, and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins.
Source:ISBN:0781765196,
PMID:16464608,
GOC:add,
PMID:17306522
Comment
Despite its name, the pre-BCR is not a receptor complex, as it appears to provide a low level of signal not dependent on a ligand, but rather simply on correct assembly of the complex as a measure for correct Ig heavy chain recombination and folding. A significant proportion of pre-BCR complexes fail to reach the cell surface, and in some cases may provide their signaling function from the trans-Golgi network or lysosome.
Link
to all annotated objects annotated to pre-B cell receptor complex.
Link
to all direct and indirect annotations
to pre-B cell receptor complex.
Link
to all direct and indirect annotations download (limited to first 10,000)
for pre-B cell receptor complex.
Feedback
Contact the
Planteome feedback
if you find mistakes or have concerns
about the data you find here.
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.