Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate (8-oxo-dGTP) + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate (8-oxo-dGMP) + diphosphate. 8-oxo-dGTP is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA.
Source:PMID:7782328,
RHEA:31575,
PMID:7859359,
PMID:17804481
Link
to all annotated objects annotated to 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity.
Link
to all direct and indirect annotations
to 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity.
Link
to all direct and indirect annotations download (limited to first 10,000)
for 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity.
Feedback
Contact the
Planteome feedback
if you find mistakes or have concerns
about the data you find here.
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.