Planteome: Term Details for "ERAD pathway" (GO:0036503)

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Term Information

Accession: GO:0036503
Name: ERAD pathway
Ontology: biological_process
Synonyms: endoplasmic reticulum-associated degradation, protein degradation by ERAD, ER-associated degradation pathway, endoplasmic reticulum-associated protein degradation pathway
Alternate IDs: None
Definition: The protein catabolic pathway which targets endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. It begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome. Source: GOC:PARL, PMID:21969857, GOC:bf, PMID:20940304
Comment: ER-associated protein degradation (ERAD) pathways target misfolded ER lumenal proteins (ERAD-L), ER membrane proteins (ERAD-M), and ER proteins with misfolded cytosolic domains (ERAD-C) by recognizing aberrant proteins, retrotranslocating these substrates to the cytosol, followed by substrate ubiquitination and proteosomal-mediated degradation. In contrast the stress-induced homeostatically regulated protein degradation (SHRED) pathway (GO:0120174), although inducible by stress, targets diverse ER membrane, and cytosolic proteins as well as numerous other native proteins in the absence of stress. Stress results in the protease-mediated (Nma111p) generation of a Roq1p cleavage product that then binds to the type-1 active site of Ubr1p, altering its substrate specificity, and leading to the proteasome-mediated degradation of both misfolded and native proteins. Although the SHRED pathway may contain some components in common with ERAD pathways (GO:0036503), such as UBR1, RAD6 and CDC48, other ERAD components, such as HRD1 and DOA10, do not appear to be involved, and as such these pathways are currently considered to be distinct.
History: See term history for GO:0036503 at QuickGO
Subset: None
Related: Link to all annotated objects annotated to ERAD pathway.; Link to all direct and indirect annotations to ERAD pathway.; Link to all direct and indirect annotations download (limited to first 10,000) for ERAD pathway.
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BFO:0000001 entity
BFO:0000003 occurrent
GO:0008150 biological_process
GO:0008152 metabolic process
BFO:0000015 process
GO:0009056 catabolic process
GO:0006807 nitrogen compound metabolic process
GO:0071704 organic substance metabolic process
GO:0009987 cellular process
GO:0043170 macromolecule metabolic process
GO:1901575 organic substance catabolic process
GO:1901564 organonitrogen compound metabolic process
GO:0044238 primary metabolic process
GO:0019538 protein metabolic process
GO:0050896 response to stimulus
GO:0051716 cellular response to stimulus
GO:0009057 macromolecule catabolic process
GO:1901565 organonitrogen compound catabolic process
GO:0030163 protein catabolic process
GO:0006508 proteolysis
GO:0042221 response to chemical
GO:0006950 response to stress
GO:0033554 cellular response to stress
GO:0051603 proteolysis involved in protein catabolic process
GO:1901698 response to nitrogen compound
GO:0010033 response to organic substance
GO:0010498 proteasomal protein catabolic process
GO:0034976 response to endoplasmic reticulum stress
GO:0010243 response to organonitrogen compound
GO:0036503 ERAD pathway
GO:0071712 ER-associated misfolded protein catabolic process
GO:1904378 maintenance of unfolded protein involved in ERAD pathway
GO:1904293 negative regulation of ERAD pathway
GO:1904294 positive regulation of ERAD pathway
GO:1904379 protein localization to cytosolic proteasome complex involved in ERAD pathway
GO:1904292 regulation of ERAD pathway
GO:0030970 retrograde protein transport, ER to cytosol
GO:0030433 ubiquitin-dependent ERAD pathway

Parents of ERAD pathway (GO:0036503)

subject	relation	object
ERAD pathway	is_a	response to organonitrogen compound (GO:0010243)
ERAD pathway	is_a	proteasomal protein catabolic process (GO:0010498)
ERAD pathway	is_a	response to endoplasmic reticulum stress (GO:0034976)

Children of ERAD pathway (GO:0036503)

subject	relation	object
ER-associated misfolded protein catabolic process (GO:0071712)	is_a	ERAD pathway
retrograde protein transport, ER to cytosol (GO:0030970)	BFO:0000050	ERAD pathway
positive regulation of ERAD pathway (GO:1904294)	RO:0002213	ERAD pathway
maintenance of unfolded protein involved in ERAD pathway (GO:1904378)	BFO:0000050	ERAD pathway
negative regulation of ERAD pathway (GO:1904293)	RO:0002212	ERAD pathway
ubiquitin-dependent ERAD pathway (GO:0030433)	is_a	ERAD pathway
regulation of ERAD pathway (GO:1904292)	RO:0002211	ERAD pathway
protein localization to cytosolic proteasome complex involved in ERAD pathway (GO:1904379)	BFO:0000050	ERAD pathway