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Term Information

Accession
GO:0039557
Name
suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity
Ontology
biological_process
Synonyms
inhibition of host IRF7 by virus, inhibition of host interferon regulatory factor-7 by virus, suppression by virus of host IRF7 activity, suppression by virus of host interferon regulatory factor 7 activity
Alternate IDs
None
Definition
Any process in which a virus stops, prevents, or reduces a host viral-induced cytoplasmic pattern recognition receptor signaling pathway by reducing the activity of IRF7 (interferon regulatory factor-7). IRF7 a transcription factor in the RIG-I/MDA-5 signaling pathway. Viral infection triggers phosphorylation of cytoplasmic IRF7, which allows IRF7 to form a homodimer, migrate to the nucleus, and activate transcription of IFN-alpha and IFN-beta genes. Source: PMID:16014964, PMID:11943871, PMID:19557165
Comment
This term is for annotation of viral proteins that counteract the host anti-viral innate immune response.
History
See term history for GO:0039557 at QuickGO
Subset
None
Feedback
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Graph of GO:0039557

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Parents of suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity (GO:0039557)
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suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity [is_a relation] is_a  suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039537)

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