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Term Information

Accession
GO:0039562
Name
disruption by virus of host JAK-STAT cascade via inhibition of STAT activity
Ontology
biological_process
Synonyms
suppression by virus of host JAK-STAT cascade via inhibition of STAT activity, suppression by virus of host STAT activity, suppression by virus of host signal transducer and activator of transcription activity, inhibition by virus of host STAT activity
Alternate IDs
None
Definition
Any process in which a virus interferes with a JAK-STAT signal cascade in a host organism by reducing the activity of host STAT (signal transducer and activator of transcription). STATs are SH2 domain-containing proteins which lie downstream of many signaling receptors. Upon phosphorylation by JAKs, STAT proteins hetero- or homo-dimerize and translocate to the nucleus to activate transcription of target genes. Source: GOC:bf
Comment
This term is for annotation of viral proteins that counteract the host anti-viral innate immune response.
History
See term history for GO:0039562 at QuickGO
Subset
None
Feedback
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Graph of GO:0039562

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Parents of disruption by virus of host JAK-STAT cascade via inhibition of STAT activity (GO:0039562)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
disruption by virus of host JAK-STAT cascade via inhibition of STAT activity [is_a relation] is_a  disruption by virus of host JAK-STAT cascade (GO:0039514)
Children of disruption by virus of host JAK-STAT cascade via inhibition of STAT activity (GO:0039562)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
disruption by virus of host JAK-STAT cascade via inhibition of STAT2 activity (GO:0039564) [is_a relation] is_a  disruption by virus of host JAK-STAT cascade via inhibition of STAT activity
disruption by virus of host JAK-STAT cascade via inhibition of STAT1 activity (GO:0039563) [is_a relation] is_a  disruption by virus of host JAK-STAT cascade via inhibition of STAT activity
None.