Planteome: Term Details for "regulation of molecular function, epigenetic" (GO:0040030)

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Term Information

Accession: GO:0040030
Name: regulation of molecular function, epigenetic
Ontology: biological_process
Synonyms: regulation of protein activity, epigenetic
Alternate IDs: None
Definition: Any heritable epigenetic process that modulates the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich ('prion') domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya. Source: GOC:dph, GOC:tb, GOC:ems, PMID:11050225, PMID:11685242, PMID:11447696, PMID:10611975, PMID:11782551
Comment: None
History: See term history for GO:0040030 at QuickGO
Subset: None
Related: Link to all annotated objects annotated to regulation of molecular function, epigenetic.; Link to all direct and indirect annotations to regulation of molecular function, epigenetic.; Link to all direct and indirect annotations download (limited to first 10,000) for regulation of molecular function, epigenetic.
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BFO:0000001 entity
BFO:0000003 occurrent
BFO:0000015 process
GO:0008150 biological_process
GO:0065007 biological regulation
GO:0003674 molecular_function
GO:0065009 regulation of molecular function
GO:0040030 regulation of molecular function, epigenetic
GO:0045857 negative regulation of molecular function, epigenetic
GO:0045858 positive regulation of molecular function, epigenetic

Parents of regulation of molecular function, epigenetic (GO:0040030)

subject	relation	object
regulation of molecular function, epigenetic	is_a	regulation of molecular function (GO:0065009)

Children of regulation of molecular function, epigenetic (GO:0040030)

subject	relation	object
positive regulation of molecular function, epigenetic (GO:0045858)	is_a	regulation of molecular function, epigenetic
negative regulation of molecular function, epigenetic (GO:0045857)	is_a	regulation of molecular function, epigenetic