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Term Information

Accession
GO:0042533
Name
tumor necrosis factor biosynthetic process
Ontology
biological_process
Synonyms
TNF alpha biosynthesis, TNF alpha biosynthetic process, TNF biosynthesis, TNF biosynthetic process, TNF-alpha biosynthesis, TNF-alpha biosynthetic process, Tumor Necrosis Factor alpha biosynthesis, Tumor Necrosis Factor alpha biosynthetic process, tumor necrosis factor anabolism, tumor necrosis factor biosynthesis, tumor necrosis factor formation, tumor necrosis factor synthesis
Alternate IDs
None
Definition
The chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis. Source: GOC:jl, PMID:10891884
Comment
Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF').
History
See term history for GO:0042533 at QuickGO
Subset
None
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Graph of GO:0042533

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Parents of tumor necrosis factor biosynthetic process (GO:0042533)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
tumor necrosis factor biosynthetic process [is_a relation] is_a  cytokine biosynthetic process (GO:0042089)
tumor necrosis factor biosynthetic process [BFO:0000050 relation] BFO:0000050  tumor necrosis factor production (GO:0032640)

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