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Term Information

Accession
GO:0042824
Name
MHC class I peptide loading complex
Ontology
cellular_component
Synonyms
peptide-loading complex, PLC
Alternate IDs
None
Definition
A large, multisubunit complex which consists of the MHC class I-beta 2 microglobulin dimer, the transporter associated with antigen presentation (TAP), tapasin (an MHC-encoded membrane protein), the chaperone calreticulin and the thiol oxidoreductase ERp57. Functions in the assembly of peptides with newly synthesized MHC class I molecules. Source: GOC:jl, PMID:10631934
Comment
Note that although this complex is located in the endoplasmic reticulum, there is some evidence that it may also be found in the Golgi.
History
See term history for GO:0042824 at QuickGO
Subset
goslim_pir
Feedback
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Graph of GO:0042824

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Parents of MHC class I peptide loading complex (GO:0042824)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
MHC class I peptide loading complex [BFO:0000050 relation] BFO:0000050  endoplasmic reticulum membrane (GO:0005789)
MHC class I peptide loading complex [is_a relation] is_a  membrane protein complex (GO:0098796)
MHC class I peptide loading complex [is_a relation] is_a  endoplasmic reticulum protein-containing complex (GO:0140534)
Children of MHC class I peptide loading complex (GO:0042824)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
Tapasin-ERp57 complex (GO:0061779) [BFO:0000050 relation] BFO:0000050  MHC class I peptide loading complex
TAP complex (GO:0042825) [BFO:0000050 relation] BFO:0000050  MHC class I peptide loading complex
None.