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Obsolete Term Information

obsolete negative regulation of molecular function, epigenetic
down regulation of protein activity, epigenetic, down-regulation of protein activity, epigenetic, downregulation of protein activity, epigenetic, negative regulation of protein activity, epigenetic, inhibition of protein activity, epigenetic
Alternate IDs
OBSOLETE. Any heritable epigenetic process that stops, prevents, or reduces the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich ('prion') domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya. Source: GOC:dph, GOC:tb, GOC:go_curators
This term was obsoleted because it is not an active process.
See term history for GO:0045857 at QuickGO
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