Planteome: Term Details for "autophagic cell death" (GO:0048102)

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Term Information

Accession: GO:0048102
Name: autophagic cell death
Ontology: biological_process
Synonyms: programmed cell death by macroautophagy, autosis, type II programmed cell death, autophagic death, programmed cell death by autophagy
Alternate IDs: None
Definition: A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells. Source: GOC:autophagy, GOC:mah, GOC:mtg_apoptosis, PMID:18846107, PMID:23347517
Comment: The precise nature of autophagic cell death is still being debated, and the link between autophagy and cell death unclear. As autophagy is often induced under conditions of stress that could also lead to cell death, there has been a propagation of the idea that autophagy can act as a cell death mechanism; but others suggest that autophagy may simply be an attempt of dying cells to adapt to lethal stress rather than a mechanism to execute a cell death program. Further studies are required to resolve this controversy (see e.g. PMID:22082964, PMID:22052193, PMID:25236395). In the meantime, curators should carefully examine the experimental evidence presented in papers concerning autophagic cell death, and annotate accordingly. Recently, an instance of autophagic cell death, termed autosis, was discovered that relies on the plasma membrane Na+/K+-ATPase. Autosis was observed in vivo in the brain of rats subjected to an ischemic insult. It's still unclear if all cases of autophagic cell death require the Na+/K+-ATPase or not.
History: See term history for GO:0048102 at QuickGO
Subset: None
Related: Link to all annotated objects annotated to autophagic cell death.; Link to all direct and indirect annotations to autophagic cell death.; Link to all direct and indirect annotations download (limited to first 10,000) for autophagic cell death.
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BFO:0000001 entity
BFO:0000003 occurrent
BFO:0000015 process
GO:0008150 biological_process
GO:0009987 cellular process
GO:0008219 cell death
GO:0012501 programmed cell death
GO:0048102 autophagic cell death
GO:1904093 negative regulation of autophagic cell death
GO:1904094 positive regulation of autophagic cell death
GO:1904092 regulation of autophagic cell death
GO:0035071 salivary gland cell autophagic cell death

Parents of autophagic cell death (GO:0048102)

subject	relation	object
autophagic cell death	is_a	programmed cell death (GO:0012501)
autophagic cell death	BFO:0000051	macroautophagy (GO:0016236)

Children of autophagic cell death (GO:0048102)

subject	relation	object
regulation of autophagic cell death (GO:1904092)	RO:0002211	autophagic cell death
salivary gland cell autophagic cell death (GO:0035071)	is_a	autophagic cell death
positive regulation of autophagic cell death (GO:1904094)	RO:0002213	autophagic cell death
negative regulation of autophagic cell death (GO:1904093)	RO:0002212	autophagic cell death