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Term Information

Accession
GO:0051870
Name
methotrexate binding
Ontology
molecular_function
Synonyms
None
Alternate IDs
None
Definition
Binding to methotrexate, an antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofolate reductase and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA. Source: GOC:nln
Comment
None
History
See term history for GO:0051870 at QuickGO
Subset
None
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Graph of GO:0051870

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Parents of methotrexate binding (GO:0051870)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
methotrexate binding [is_a relation] is_a  carboxylic acid binding (GO:0031406)
methotrexate binding [is_a relation] is_a  amide binding (GO:0033218)
methotrexate binding [is_a relation] is_a  organic cyclic compound binding (GO:0097159)
methotrexate binding [is_a relation] is_a  heterocyclic compound binding (GO:1901363)
methotrexate binding [is_a relation] is_a  modified amino acid binding (GO:0072341)

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