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canonical Wnt signaling pathway

Term Information

Accession
GO:0060070
Name
canonical Wnt signaling pathway
Ontology
biological_process
Synonyms
Wnt receptor signaling pathway through beta-catenin, Wnt receptor signaling pathway via beta-catenin, Wnt receptor signalling pathway through beta-catenin, canonical Wnt receptor signaling pathway, canonical Wnt-activated signaling pathway, frizzled-1 receptor signaling pathway
Alternate IDs
None
Definition
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. Source: GOC:dph, PMID:11532397, PMID:19619488, GOC:bf
Comment
None
History
See term history for GO:0060070 at QuickGO
Subset
None
Feedback
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Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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Graph of GO:0060070

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Parents of canonical Wnt signaling pathway (GO:0060070)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
canonical Wnt signaling pathway [is_a relation] is_a  Wnt signaling pathway (GO:0016055)
Children of canonical Wnt signaling pathway (GO:0060070)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation (GO:1904954) [is_a relation] is_a  canonical Wnt signaling pathway
regulation of canonical Wnt signaling pathway (GO:0060828) [RO:0002211 relation] RO:0002211  canonical Wnt signaling pathway
canonical Wnt signaling pathway involved in positive regulation of endothelial cell migration (GO:0044328) [is_a relation] is_a  canonical Wnt signaling pathway
negative regulation of canonical Wnt signaling pathway (GO:0090090) [RO:0002212 relation] RO:0002212  canonical Wnt signaling pathway
canonical Wnt signaling pathway involved in neural crest cell differentiation (GO:0044335) [is_a relation] is_a  canonical Wnt signaling pathway
canonical Wnt signaling pathway involved in positive regulation of wound healing (GO:0044330) [is_a relation] is_a  canonical Wnt signaling pathway
canonical Wnt signaling pathway involved in mesonephros development (GO:0061292) [is_a relation] is_a  canonical Wnt signaling pathway
canonical Wnt signaling pathway involved in regulation of cell proliferation (GO:0044340) [is_a relation] is_a  canonical Wnt signaling pathway
beta-catenin destruction complex disassembly (GO:1904886) [BFO:0000050 relation] BFO:0000050  canonical Wnt signaling pathway
coreceptor activity involved in canonical Wnt signaling pathway (GO:1904928) [BFO:0000050 relation] BFO:0000050  canonical Wnt signaling pathway
canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation (GO:0044338) [is_a relation] is_a  canonical Wnt signaling pathway
canonical Wnt signaling pathway involved in positive regulation of cell-cell adhesion (GO:0044329) [is_a relation] is_a  canonical Wnt signaling pathway
canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation (GO:0060823) [is_a relation] is_a  canonical Wnt signaling pathway
canonical Wnt signaling pathway involved in metanephric kidney development (GO:0061290) [is_a relation] is_a  canonical Wnt signaling pathway
positive regulation of spinal cord association neuron differentiation by canonical Wnt signaling pathway (GO:0100067) [is_a relation] is_a  canonical Wnt signaling pathway
canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition (GO:0044334) [is_a relation] is_a  canonical Wnt signaling pathway
positive regulation of canonical Wnt signaling pathway (GO:0090263) [RO:0002213 relation] RO:0002213  canonical Wnt signaling pathway
canonical Wnt signaling pathway involved in heart development (GO:0061316) [is_a relation] is_a  canonical Wnt signaling pathway
canonical Wnt signaling pathway involved in positive regulation of apoptotic process (GO:0044337) [is_a relation] is_a  canonical Wnt signaling pathway
receptor internalization involved in canonical Wnt signaling pathway (GO:2000286) [BFO:0000050 relation] BFO:0000050  canonical Wnt signaling pathway
regulation of heart induction by canonical Wnt signaling pathway (GO:0100012) [is_a relation] is_a  canonical Wnt signaling pathway
canonical Wnt signaling pathway involved in negative regulation of apoptotic process (GO:0044336) [is_a relation] is_a  canonical Wnt signaling pathway
regulation of hair cycle by canonical Wnt signaling pathway (GO:0060901) [is_a relation] is_a  canonical Wnt signaling pathway
canonical Wnt signaling pathway involved in osteoblast differentiation (GO:0044339) [is_a relation] is_a  canonical Wnt signaling pathway
None.