Planteome: Term Details for "RISC-loading complex" (GO:0070578)

Accession: GO:0070578
Name: RISC-loading complex
Ontology: cellular_component
Synonyms: miRLC, microRNA loading complex, RLC
Alternate IDs: None
Definition: A trimeric protein complex required for the formation of a mature RNA-induced silencing complex (RISC). In humans the complex is composed of the endonuclease Dicer (DICER1), TRBP (TARBP2) and the Argonaute protein Ago2 (EIF2C2/AGO2). Within the complex, Dicer and TRBP are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto Ago2. Ago2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from Dicer and TRBP. This complex has endoribonuclease activity. Source: GOC:rph, PMID:19820710, GOC:BHF, GOC:ab, PMID:18178619, GOC:nc
Comment: None
History: See term history for GO:0070578 at QuickGO
Subset: None
Related: Link to all annotated objects annotated to RISC-loading complex.; Link to all direct and indirect annotations to RISC-loading complex.; Link to all direct and indirect annotations download (limited to first 10,000) for RISC-loading complex.
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