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Term Information

Accession
GO:0070877
Name
microprocessor complex
Ontology
cellular_component
Synonyms
None
Alternate IDs
None
Definition
A protein complex that binds to heme and to pri-miRNAs, and is required for the formation of a pre-microRNA (pre-miRNA), the initial step of microRNA (miRNA) biogenesis. The complex is composed of the double-stranded-RNA-specific RNase Drosha (also called RNASEN) and the RNA-binding protein DGCR8 (heme-free or heme-bound forms). Within the complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs RNASEN/Drosha to cleave the 3' and 5' strands of a stem-loop to release hairpin-shaped pre-miRNAs. Source: PMID:16963499, PMID:17159994
Comment
None
History
See term history for GO:0070877 at QuickGO
Subset
None
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Graph of GO:0070877

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Parents of microprocessor complex (GO:0070877)
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microprocessor complex [is_a relation] is_a  nuclear protein-containing complex (GO:0140513)
microprocessor complex [is_a relation] is_a  ribonuclease III complex (GO:1903095)

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None.