Planteome: Term Details for "CAAX-box protein maturation" (GO:0080120)

Term Information

Accession: GO:0080120
Name: CAAX-box protein maturation
Ontology: biological_process
Synonyms: CAAX-box protein processing, farnesylated protein maturation
Alternate IDs: None
Definition: A series of specific posttranslational modifications to the CAAX box region of CAAX box proteins. CAAX box proteins are eukaryotic proteins that contain a CAAX motif where the C is a cysteine, the two A residues are aliphatic amino acids and the X can be one of several amino acids. The CAAX-box proteins undergo three sequential, enzymatic, post-translational modifications essential to their targeting: First, the proteins are prenylated by one of two prenyltransferases called farnesyltransferase and geranylgeranyltransferase-I. Prenylation results in the covalent attachment of either farnesyl or geranylgeranyl isoprenoid groups to the cysteine in the CAAX box motif. Prenylation is followed by proteolytic removal of the last three amino acids of the protein (AAX). Finally, the newly exposed carboxylate group of the isoprenylcysteine is methylated by an ER-associated prenyl-dependent carboxylmethyltransferase. Source: PMID:17114793, PMID:18641086, PMID:12039957
Comment: None
History: See term history for GO:0080120 at QuickGO
Subset: None
Related: Link to all annotated objects annotated to CAAX-box protein maturation.; Link to all direct and indirect annotations to CAAX-box protein maturation.; Link to all direct and indirect annotations download (limited to first 10,000) for CAAX-box protein maturation.
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BFO:0000001 entity
BFO:0000003 occurrent
BFO:0000015 process
GO:0008150 biological_process
GO:0008152 metabolic process
GO:0009987 cellular process
GO:0006807 nitrogen compound metabolic process
GO:0071704 organic substance metabolic process
GO:0044237 cellular metabolic process
GO:0043170 macromolecule metabolic process
GO:1901564 organonitrogen compound metabolic process
GO:0044238 primary metabolic process
GO:0044260 cellular macromolecule metabolic process
GO:0010467 gene expression
GO:0019538 protein metabolic process
GO:0044267 cellular protein metabolic process
GO:0051604 protein maturation
GO:0080120 CAAX-box protein maturation
GO:0071587 CAAX-box protein modification
GO:0071586 CAAX-box protein processing

Parents of CAAX-box protein maturation (GO:0080120)

subject	relation	object
CAAX-box protein maturation	is_a	protein maturation (GO:0051604)
CAAX-box protein maturation	BFO:0000051	protein prenylation (GO:0018342)
CAAX-box protein maturation	is_a	cellular protein metabolic process (GO:0044267)
CAAX-box protein maturation	BFO:0000051	protein processing (GO:0016485)

Children of CAAX-box protein maturation (GO:0080120)

subject	relation	object
CAAX-box protein processing (GO:0071586)	BFO:0000050	CAAX-box protein maturation
CAAX-box protein modification (GO:0071587)	BFO:0000050	CAAX-box protein maturation

CAAX-box protein maturation

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Parents of CAAX-box protein maturation (GO:0080120)

Children of CAAX-box protein maturation (GO:0080120)

None.