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Term Information

Accession
GO:0097345
Name
mitochondrial outer membrane permeabilization
Ontology
biological_process
Synonyms
MOMP, mitochondrial outer membrane permeabilization, mitochondrial outer membrane permeabilization during apoptotic cell death
Alternate IDs
None
Definition
The process by which the mitochondrial outer membrane becomes permeable to the passing of proteins and other molecules from the intermembrane space to the cytosol as part of the apoptotic signaling pathway. Source: GOC:BHF, PMID:21041309, GOC:mtg_apoptosis, GOC:pg
Comment
BAX and BAK are involved in this process, as reviewed in PMID:21760595 (the human proteins have UniProt symbols Q07812 and Q16611 respectively).
History
See term history for GO:0097345 at QuickGO
Subset
None
Feedback
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Graph of GO:0097345

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Parents of mitochondrial outer membrane permeabilization (GO:0097345)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
mitochondrial outer membrane permeabilization [BFO:0000050 relation] BFO:0000050  apoptotic signaling pathway (GO:0097190)
mitochondrial outer membrane permeabilization [is_a relation] is_a  positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110)
Children of mitochondrial outer membrane permeabilization (GO:0097345)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
protein insertion into mitochondrial membrane involved in apoptotic signaling pathway (GO:0001844) [BFO:0000050 relation] BFO:0000050  mitochondrial outer membrane permeabilization
regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway (GO:1901028) [RO:0002211 relation] RO:0002211  mitochondrial outer membrane permeabilization
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway (GO:1901029) [RO:0002212 relation] RO:0002212  mitochondrial outer membrane permeabilization
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway (GO:1901030) [RO:0002213 relation] RO:0002213  mitochondrial outer membrane permeabilization
None.