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double-strand break repair via alternative nonhomologous end joining
Term Information
Accession
GO:0097681
Name
double-strand break repair via alternative nonhomologous end joining
Ontology
biological_process
Synonyms
double-strand break repair via microhomology-mediated end joining, A-NHEJ, MMEJ, alt-NHEJ
Alternate IDs
None
Definition
An instance of double-strand break repair via nonhomologous end joining that is independent of factors important for V(D)J recombination (as opposed to classical nonhomologous end joining). It often results in a deletion with microhomology (i.e. 5-25bp homology) at the repair junction. Among different subclasses of nonhomologous end joining (NHEJ), alternative NHEJ appears to play a significant role in the etiology of mutations that arise during cancer development and treatment.
Source:
GOC:rph,
PMID:18584027,
PMID:21655080,
Wikipedia:Microhomology-mediated_end_joining
Link
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Link
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to double-strand break repair via alternative nonhomologous end joining.
Link
to all direct and indirect annotations download (limited to first 10,000)
for double-strand break repair via alternative nonhomologous end joining.
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