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Term Information

Accession
GO:0101005
Name
deubiquitinase activity
Ontology
molecular_function
Synonyms
ubiquitinyl hydrolase activity
Alternate IDs
GO:1904265
Definition
An isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated. Source: GOC:mec, PMID:30783221
Comment
There are two main classes of deubiquitinating enzymes: cysteine proteases (i.e., thiol dependent) and metalloproteases.
History
See term history for GO:0101005 at QuickGO
Subset
None
Feedback
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Graph of GO:0101005

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Parents of deubiquitinase activity (GO:0101005)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
deubiquitinase activity [is_a relation] is_a  ubiquitin-like protein peptidase activity (GO:0019783)
Children of deubiquitinase activity (GO:0101005)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
histone deubiquitinase activity (GO:0140934) [is_a relation] is_a  deubiquitinase activity
K63-linked deubiquitinase activity (GO:0061578) [is_a relation] is_a  deubiquitinase activity
K11-linked deubiquitinase activity (GO:0180017) [is_a relation] is_a  deubiquitinase activity
cysteine-type deubiquitinase activity (GO:0004843) [is_a relation] is_a  deubiquitinase activity
metal-dependent deubiquitinase activity (GO:0140492) [is_a relation] is_a  deubiquitinase activity
K48-linked deubiquitinase activity (GO:1990380) [is_a relation] is_a  deubiquitinase activity
Reactome
R-HSA-9674127