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Term Information

Accession
GO:0140416
Name
transcription regulator inhibitor activity
Ontology
molecular_function
Synonyms
DNA-binding transcription factor inhibitor activity
Alternate IDs
None
Definition
A molecular function regulator that inhibits the activity of a transcription regulator via direct binding and/or post-translational modification. Source: PMID:10652346
Comment
Usage guidance: transcription regulator inhibitors bind to a transcription regulator to prevent it from reaching the chromatin. This activity does not occur at the promoter. For activities that do occur at the promoter, consider GO:0001217 ; DNA-binding transcription repressor activity or GO:0003714 ; transcription corepressor activity. An example of a transcription regulator is TCF23 Q7RTU1 is an example of a protein that regulates transcription factors by heterodimerising or binding to DbTFs and prevent DNA binding and their specific genomic binding site where the dbTF would have activated or repressed transcription. Also an example is NFKBIA P25963 which has a different way of regulating transcription factor activity by sequestering the dbTF (complex) in the cytoplasm. Another example is the HSP90 and HSP23 proteins that sequester steroid receptors away from the DNA.
History
See term history for GO:0140416 at QuickGO
Subset
None
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Graph of GO:0140416

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Parents of transcription regulator inhibitor activity (GO:0140416)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
transcription regulator inhibitor activity [BFO:0000050 relation] BFO:0000050  regulation of gene expression (GO:0010468)
transcription regulator inhibitor activity [is_a relation] is_a  molecular function inhibitor activity (GO:0140678)

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