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ATAC complex
Term Information
Accession
GO:0140672
Name
ATAC complex
Ontology
cellular_component
Synonyms
ADA2A-containing complex, Ada Two-A containing complex, Ada two A containing complex, Ada-Two-A-containing complex, G-ATAC complex, KAT2A-containing ATAC complex, KAT2B-containing ATAC complex
Alternate IDs
None
Definition
A chromatin remodeling complex that regulates transcription via acetylation primarily of nucleosomal histones H3 and possibly H4. Shares the histone acetylation (HAT) module of GCN5/PCAF-ADA2-ADA3-SGF29 (or orthologs) with the related SAGA complex (GO:0000124). Contains HAT subunits GCN5 or PCAF in a mutually exclusive manner. In addition to the HAT module contains DR1/NC2B, KAT14, MBIP, WDR5, YEATS2 and ZZZ3 or orthologs. Also regulates the activity of non-histone targets and orchestrates mitotic progression by regulating Cyclin A degradation through acetylation.
Source:PMID:19936620,
PMID:28966424,
PMID:20562830,
GOC:bhm
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