Planteome: Term Details for "amphiregulin production" (GO:0140730)

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Term Information

Accession: GO:0140730
Name: amphiregulin production
Ontology: biological_process
Synonyms: AREG production
Alternate IDs: None
Definition: The appearance of amphiregulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Amphiregulin (AREG) is a ligand of the epidermal growth factor receptor (EGFR), a widely expressed transmembrane tyrosine kinase. AREG is synthesized as a membrane-anchored precursor protein that can engage in juxtacrine signaling on adjacent cells. Alternatively, after proteolytic processing by cell membrane proteases, mainly TACE/ADAM17, AREG is secreted and behaves as an autocrine or paracrine factor. Source: PMID:24463227
Comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
History: See term history for GO:0140730 at QuickGO
Subset: gocheck_do_not_annotate
Related: Link to all annotated objects annotated to amphiregulin production.; Link to all direct and indirect annotations to amphiregulin production.; Link to all direct and indirect annotations download (limited to first 10,000) for amphiregulin production.
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GO:0008150 biological_process
BFO:0000001 entity
BFO:0000003 occurrent
GO:0008152 metabolic process
GO:0071704 organic substance metabolic process
BFO:0000015 process
GO:0043170 macromolecule metabolic process
GO:0010467 gene expression
GO:0032501 multicellular organismal process
GO:0001816 cytokine production
GO:0140730 amphiregulin production
GO:0140732 positive regulation of amphiregulin production
GO:0140731 regulation of amphiregulin production

Parents of amphiregulin production (GO:0140730)

subject	relation	object
amphiregulin production	is_a	cytokine production (GO:0001816)

Children of amphiregulin production (GO:0140730)

subject	relation	object
positive regulation of amphiregulin production (GO:0140732)	RO:0002213	amphiregulin production
regulation of amphiregulin production (GO:0140731)	RO:0002211	amphiregulin production