Planteome: Term Details for "siRNA-mediated gene silencing" (GO:0140766)

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Term Information

Accession: GO:0140766
Name: siRNA-mediated gene silencing
Ontology: biological_process
Synonyms: gene silencing by siRNA, post-transcriptional gene silencing by siRNA, posttranscriptional gene silencing by siRNA, siRNA-mediated PTGS
Alternate IDs: None
Definition: A post-transcriptional gene silencing pathway in which small interfering RNAs (siRNAs) elicit silencing of specific target genes. siRNAs are 21-23 nucleotide RNA duplexes that are fully complementary to their target mRNA. siRNAs can be exported and act in other cells, including in germline cells. Once incorporated into a RNA-induced silencing complex (RISC), siRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: endonucleolytic cleavage of the mRNA or mRNA translational repression. siRNAs are present in lower animals and plants, but not found in mammals; whereas miRNAs are present in all the animals and in plants. Source: PMID:26372022
Comment: None
History: See term history for GO:0140766 at QuickGO
Subset: None
Related: Link to all annotated objects annotated to siRNA-mediated gene silencing.; Link to all direct and indirect annotations to siRNA-mediated gene silencing.; Link to all direct and indirect annotations download (limited to first 10,000) for siRNA-mediated gene silencing.
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BFO:0000001 entity
BFO:0000003 occurrent
GO:0008150 biological_process
GO:0065007 biological regulation
BFO:0000015 process
GO:0008152 metabolic process
GO:0050789 regulation of biological process
GO:0043170 macromolecule metabolic process
GO:0048519 negative regulation of biological process
GO:0071704 organic substance metabolic process
GO:0019222 regulation of metabolic process
GO:0010467 gene expression
GO:0009892 negative regulation of metabolic process
GO:0060255 regulation of macromolecule metabolic process
GO:0010605 negative regulation of macromolecule metabolic process
GO:0010468 regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010608 post-transcriptional regulation of gene expression
GO:0016441 post-transcriptional gene silencing
GO:0031047 regulatory ncRNA-mediated gene silencing
GO:0035194 regulatory ncRNA-mediated post-transcriptional gene silencing
GO:0140766 siRNA-mediated gene silencing
GO:0070549 siRNA-mediated gene silencing by inhibition of translation
GO:0090625 siRNA-mediated gene silencing by mRNA destabilization

Parents of siRNA-mediated gene silencing (GO:0140766)

subject	relation	object
siRNA-mediated gene silencing	is_a	regulatory ncRNA-mediated post-transcriptional gene silencing (GO:0035194)

Children of siRNA-mediated gene silencing (GO:0140766)

subject	relation	object
siRNA-mediated gene silencing by inhibition of translation (GO:0070549)	is_a	siRNA-mediated gene silencing
siRNA-mediated gene silencing by mRNA destabilization (GO:0090625)	is_a	siRNA-mediated gene silencing