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Bre1-Rad6 ubiquitin ligase complex

Term Information

Accession
GO:1990302
Name
Bre1-Rad6 ubiquitin ligase complex
Ontology
cellular_component
Synonyms
Bre1-Rad6 complex
Alternate IDs
None
Definition
A ubiquitin ligase complex consisting of Bre1 and Rad6 that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. It thereby plays a central role in histone code and gene regulation. It also modulates the formation of double-strand breaks during meiosis. Source: PMID:19531475, GOC:bhm
Comment
This complex has been identified in Saccharomyces cerevisiae (P19812) - see PMID:19531475 (inferred from direct assay).
History
See term history for GO:1990302 at QuickGO
Subset
None
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Graph of GO:1990302

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Parents of Bre1-Rad6 ubiquitin ligase complex (GO:1990302)
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Bre1-Rad6 ubiquitin ligase complex [BFO:0000050 relation] BFO:0000050  intracellular anatomical structure (GO:0005622)
Bre1-Rad6 ubiquitin ligase complex [is_a relation] is_a  transferase complex (GO:1990234)

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