Planteome: Term Details for "Ire1 complex" (GO:1990332)

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Term Information

Accession: GO:1990332
Name: Ire1 complex
Ontology: cellular_component
Synonyms: IRE1 dimer, ERN1 complex
Alternate IDs: None
Definition: A type-I transmembrane protein complex located in the endoplasmic reticulum (ER) consisting of an IRE1-IRE1 dimer, which forms in response to the accumulation of unfolded protein in the ER. The dimeric complex has endoribonuclease (RNase) activity and evokes the unfolded protein response (UPR) by cleaving an intron of a mRNA coding for the transcription factor HAC1 in yeast or XBP1 in mammals; the complex cleaves a single phosphodiester bond in each of two RNA hairpins (with non-specific base paired stems and loops of consensus sequence CNCNNGN, where N is any base) to remove an intervening intron from the target transcript. Source: PMID:25437541, GOC:bf, PMID:18191223, GOC:bhm
Comment: An example of this is Ire1 in Escherichia coli (P32361) in PMID:18191223 (inferred from direct assay).
History: See term history for GO:1990332 at QuickGO
Subset: None
Related: Link to all annotated objects annotated to Ire1 complex.; Link to all direct and indirect annotations to Ire1 complex.; Link to all direct and indirect annotations download (limited to first 10,000) for Ire1 complex.
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GO:1902494 catalytic complex
GO:0110165 cellular anatomical entity
GO:0005622 intracellular anatomical structure
GO:0043226 organelle
GO:0005575 cellular_component
GO:0043229 intracellular organelle
GO:0043227 membrane-bounded organelle
GO:0032991 protein-containing complex
GO:1990234 transferase complex
GO:0005737 cytoplasm
GO:0012505 endomembrane system
GO:0005783 endoplasmic reticulum
GO:0043231 intracellular membrane-bounded organelle
GO:0140535 intracellular protein-containing complex
GO:0016020 membrane
GO:0031984 organelle subcompartment
GO:0061695 transferase complex, transferring phosphorus-containing groups
GO:1905348 endonuclease complex
GO:0098827 endoplasmic reticulum subcompartment
GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network
GO:0031090 organelle membrane
GO:1902911 protein kinase complex
GO:0005789 endoplasmic reticulum membrane
GO:0140534 endoplasmic reticulum protein-containing complex
GO:1902555 endoribonuclease complex
GO:0098796 membrane protein complex
GO:1902554 serine/threonine protein kinase complex
GO:1990332 Ire1 complex

Parents of Ire1 complex (GO:1990332)

subject	relation	object
Ire1 complex	is_a	membrane protein complex (GO:0098796)
Ire1 complex	is_a	endoribonuclease complex (GO:1902555)
Ire1 complex	BFO:0000050	endoplasmic reticulum membrane (GO:0005789)
Ire1 complex	is_a	endoplasmic reticulum protein-containing complex (GO:0140534)
Ire1 complex	is_a	serine/threonine protein kinase complex (GO:1902554)

This term has no children.

Ire1 complex

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Parents of Ire1 complex (GO:1990332)

None.