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CLOCK-BMAL transcription complex
Term Information
Accession
GO:1990513
Name
CLOCK-BMAL transcription complex
Ontology
cellular_component
Synonyms
CLOCK/BMAL complex
Alternate IDs
None
Definition
Transcription factor complex which interacts with E-box regulatory elements in target genes, including Period (Per1, Per2, Per3) and Cryptochrome (Cry1, Cry2), to activate their transcription during the daytime. The CRY-PER complexes inhibit CLOCK-BMAL1-driven transcription in a negative feedback loop to generate circadian rhythms.
Source:PMID:23229515,
GOC:bhm
Comment
An example of this is CLOCK in human (O15516) in PMID:23229515 (inferred from physical interaction).
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