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C/EBP complex

Term Information

Accession
GO:1990647
Name
C/EBP complex
Ontology
cellular_component
Synonyms
C/EBP homodimer complex, C/EBP transcription factor complex, C/EBPalpha complex, C/EBPalpha homodimer complex, C/EBPbeta complex, C/EBPbeta homodimer complex
Alternate IDs
None
Definition
A dimeric, sequence specific DNA-binding transcription factor complex regulating the expression of genes involved in immune and inflammatory responses. Exists at least as alpha and beta homodimeric forms. Binds to regulatory regions of several acute-phase and cytokines genes and probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Transcription factor activity is inhibited by binding of CHOP forming heterodimers with alternative transcription factor activities. Source: GOC:PARL, PMID:8657121, GOC:pad, GOC:bhm
Comment
An example of this is Cebpa in rat (P05554) in PMID:8657121 (inferred from direct assay).
History
See term history for GO:1990647 at QuickGO
Subset
None
Feedback
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Graph of GO:1990647

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Parents of C/EBP complex (GO:1990647)
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C/EBP complex [is_a relation] is_a  RNA polymerase II transcription regulator complex (GO:0090575)

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