Planteome: Term Details for "iNOS-S100A8/A9 complex" (GO:1990657)

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Term Information

Accession: GO:1990657
Name: iNOS-S100A8/A9 complex
Ontology: cellular_component
Synonyms: None
Alternate IDs: None
Definition: A protein complex capable of stimulus-inducible nitric-oxide synthase activity. S-nitrosylates cysteine residues in target proteins, a principal mechanism of nitric oxide (NO)-mediated signal transduction. In mammals consists of NOS2, S100A8 and S100A9. S100A9 acts both as an adaptor linking NOS2 to its target and as a transnitrosylase that transfers the nitric oxide moiety from NOS2 to its target, via its own S-nitrosylated cysteine. Source: PMID:25417112, GOC:bhm
Comment: An example of this is NOS2 in human (UniProt symbol P35228) in PMID:25417112 (inferred from direct assay).
History: See term history for GO:1990657 at QuickGO
Subset: None
Related: Link to all annotated objects annotated to iNOS-S100A8/A9 complex.; Link to all direct and indirect annotations to iNOS-S100A8/A9 complex.; Link to all direct and indirect annotations download (limited to first 10,000) for iNOS-S100A8/A9 complex.
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