Planteome: Term Details for "cell death" (GO:0008219)

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Term Information

Accession: GO:0008219
Name: cell death
Ontology: biological_process
Synonyms: accidental cell death, necrosis
Alternate IDs: None
Definition: Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538). Source: PMID:25236395, GOC:mah, GOC:mtg_apoptosis
Comment: This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide) show that cell death has occurred, but fail to provide details on death modality (accidental versus programmed). When information is provided on the cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Also, if experimental data suggest that a gene product influences cell death indirectly, rather than being involved in the death process directly, consider annotating to a 'regulation' term.
History: See term history for GO:0008219 at QuickGO
Subset: goslim_drosophila; goslim_chembl; goslim_generic; goslim_plant; goslim_mouse; goslim_agr
Related: Link to all annotated objects annotated to cell death.; Link to all direct and indirect annotations to cell death.; Link to all direct and indirect annotations download (limited to first 10,000) for cell death.
Feedback: Contact the Planteome feedback if you find mistakes or have concerns about the data you find here.
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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BFO:0000001 entity
BFO:0000003 occurrent
BFO:0000015 process
GO:0008150 biological_process
GO:0009987 cellular process
GO:0008219 cell death
GO:0036473 cell death in response to oxidative stress
GO:0070265 necrotic cell death
GO:0060548 negative regulation of cell death
GO:0070997 neuron death
GO:0010942 positive regulation of cell death
GO:0012501 programmed cell death
GO:0010941 regulation of cell death

Parents of cell death (GO:0008219)

subject	relation	object
cell death	is_a	cellular process (GO:0009987)

Children of cell death (GO:0008219)

subject	relation	object
positive regulation of cell death (GO:0010942)	RO:0002213	cell death
programmed cell death (GO:0012501)	is_a	cell death
neuron death (GO:0070997)	is_a	cell death
regulation of cell death (GO:0010941)	RO:0002211	cell death
negative regulation of cell death (GO:0060548)	RO:0002212	cell death
cell death in response to oxidative stress (GO:0036473)	is_a	cell death
necrotic cell death (GO:0070265)	is_a	cell death